Protected slit diaphragm integrity in human immortalized podocytes in response to treatment with histamine (Veglia et al., 2016); reversed leptin‐induced rise in mean arterial pressure, heart rate, and renal blood flow in rat model of hemorrhagic shock (Jochem et al., 2016); reduced blood levels of IL‐6, IL‐1β, and TNF‐α, reduced tissue levels of IL‐1β, ILβ6, and TNF‐α mRNAs, reduced levels of NGAL, serum BUN, and creatinine in mouse model of sepsis (Hattori et al., 2016). The gene discussed is TNF; the disease is Sepsis.