If certain characteristics differed between each group (overexpression of BRAF mutated melanoma in group 2 and overexpression of mucosal melanoma in group 1) most clinical characteristics associated with a pejorative response to CC (presence or absence of a brain metastasis, AJCC staging, number of metastasis, and LDH level at chemotherapy initiation...) were similar in both groups.55 This evidence concerns the gene BRAF and melanoma.