We found a strong negative correlation between both factors in luminal A type [estrogen receptor (ER)+, progesterone receptor (PR)+, human epidermal growth factor receptor‐2 (HER2)–], HER2 enriched type (ER/PR−, HER2+), and in triple negative breast cancer type (TNBC), demonstrating that SENP3 could suppress M2 polarization in general (Table 3). Here, ESR1 is linked to triple-negative breast carcinoma.