In line with CD206 upregulation in the tumor tissues within cKO mice, other M2 subtype markers, such as transforming growth factor (TGF‐β), resistin‐like molecule alpha/Fizz1, metabotropic glutamate receptor (Mgl‐1), vascular endothelial growth factor (VEGF), matrix metallopeptidase 2 (MMP2) and MMP9, were notably increased in Senp3 cKO BMDM 6 h after treatment with IL‐4/IL‐13 (Fig. 3A,B). This evidence concerns the gene MRC1 and neoplasm.