KLF4 and neoplasm: However, except that the effect of SUMOylation of KLF4 on promotion of M2 polarization is limited in RAW264.7 cells, the regulatory role of protein SUMOylation or de‐SUMOylation has been less studied during the reprogramming process of macrophage polarity towards ‘pro‐tumor’ M2 subtype [9, 39, 40, 44].