To determine whether SENP3 plays a role in macrophages during breast cancer progression, we first generated macrophage‐specific Senp3 knockout mice (Senp3 cKO) by crossing Senp3fl/fl mice with lysozyme 2 (Lyz2) Cre mice; the disruption of Senp3 in BMDM was then verified by quantitative RT‐PCR (qRT‐PCR) analysis (Fig. S1A). The gene discussed is LYZL2; the disease is breast cancer.