The current work revealed the basic pathway of IGF‐1R’s nuclear localization, which provides an important reference to identify targets that inhibit the nuclear localization of IGF‐1R; 4) current work showed that nuclear‐localized IGF‐1R is closely related to the hyperactivation of STAT3, and STAT3 itself is an important signalling molecule closely related with cell malignancy,29, 30, 31, 32 which suggests that nuclear‐localized IGF‐1R may be closely involved in the occurrence and development of intestinal tumours. The gene discussed is STAT3; the disease is intestinal neoplasm.