LncRNAs regulate the sensitivity of lung cancer cells to EGFR‐TKIs chiefly through one of the following mechanisms: 1) MAPK/ERK signaling pathway, 2) PI3K/AKT/mTOR signaling pathway, 3) STAT3 signaling pathway, 4) mitochondrial pathway, 5) cell cycle progression, or 6) EMT (Figure 3). The gene discussed is STAT3; the disease is lung cancer.