LncRNAs mainly regulate the chemosensitivity of lung cancer cells through the following mechanisms: 1) MAPK/ERK signaling pathway, 2) PI3K/AKT/mTOR and NF‐κB signaling pathway, 3) mitochondrial pathway, 4) STAT3 signaling pathway, 5) affecting cancer cell stemness by regulating the Wnt/β‐catenin signaling pathway, 6) activating or inactivating Beclin‐1 through crosstalk between apoptosis and autophagy, 7) epithelial to mesenchymal transition (EMT), 8) autophagy, and 9) multidrug resistance (MDR) (Figure 1). The gene discussed is MTOR; the disease is lung cancer.