We next introduced concomitantly expressed hMet and an S45 to tyrosine (Y) mutant form of β‐catenin (S45Y‐β‐catenin, with a Myc tag) using SB transposon/transposase (henceforth referred to as hMetS45Y‐β‐catenin model) to C57BL/6 mice via hydrodynamic tail vein injection to model human HCC in mice as previously described.30 The gene discussed is MYC; the disease is hepatocellular carcinoma.