The role of membrane raft proteome in mediating cholesterol‐associated metastasis was previously highlighted in our prostate cancer xenograft hypercholesterolemic diet study,55 which identified a cholesterol‐responsive protein, IQGAP1, that mediates cell migration and invasion and was essential for hypercholesterolemia‐induced metastasis in vivo.55 This evidence concerns the gene IQGAP1 and Familial prostate cancer.