Our data revealed that CD209+CD36+ TAMs were more existed in the advanced stage of NB, while CD80+CCR7+ TAMs as well as CD14+CD16– classic monocytes were more existed in tissues and PBMCs of early‐stage NB, indicating the tumor‐inhibiting and tumor‐promoting TME in early and advanced NB environment, respectively. The gene discussed is CD14; the disease is neoplasm.