These unique features render GBM cells addicted to exogenous cholesterol supply for their survival and more susceptible to cell death upon cholesterol depletion by treatment with LXR agonists that stimulate ABCA1‐dependent cholesterol efflux and inhibit cholesterol uptake by promoting the IDOL‐mediated LDLR degradation [8, 9, 52]. The gene discussed is ABCA1; the disease is glioblastoma.