SNX14 and Anxiety: In fact, SNX14, a brain-enriched SNX, has been categorized as a dual endogenous negative regulator of neuronal 5-HT6 receptor signaling, a receptor important for cognition and anxiety [65] (Fig. 4c), by inhibiting signaling and trafficking of 5-HT6R. On one hand, SNX14 interaction with the receptor promotes its degradation, and on the other hand its RGS domain associates and sequesters Gαs, inhibiting downstream cAMP production.