Based on the effect of the CPT1 antagonist in the SOD1 G93A model and our previous results showing that Cpt1aP479L/P479L mutated mice are resistant to the experimental autoimmune encephalomyelitis (EAE) model20, we tested the effect of crossing Cpt1aP479L/P479L mutated female mice with SOD1 G93A male mice. This evidence concerns the gene SOD1 and experimental autoimmune encephalomyelitis.