FH and hereditary leiomyomatosis and renal cell cancer: These data also provide insight into a post-translational modification event that results from the inactivation of FH activity in HLRCC characterized within clinically-relevant tissue samples, where 367 2SC-modified peptides were directly observed and quantified by MS, among which 53 have been observed in cell line models of HLRCC26 and 18 also described in FH mutant human tissues23 (Supplemental Table 17).