We assessed 16 transcripts associated with glycolysis and gluconeogenesis signaling in our dataset and found enolase 2 among this subset as significantly altered (ENO2, LogFC + 1.02 in HLRCC vs NS ULMs) in ULMs from EA vs AA women (LogFC − 0.64, LIMMA P < 0.05), suggesting alterations observed in the majority of these cases are not impacted by patient race. Here, ENO2 is linked to hereditary leiomyomatosis and renal cell cancer.