Pathway analyses of those positively correlated (111, Spearman Rho > 0.6) in HLRCC ULMs revealed enrichment of pathways correlating with metabolism, namely the 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 (PFKFB4) pathways as well as aerobic respiration, (tricarboxylic acid cycle II). The gene discussed is PFKFB4; the disease is hereditary leiomyomatosis and renal cell cancer.