This subset of 51 transcript:protein pairs validate previously defined alteration trends and represent highly conserved alterations in HLRCC ULMs including multiple candidates containing ARE gene promoter motifs that are likely NRF2 transcriptional targets as well as those regulating key steps in glycolysis, such as alpha-enolase (ENO1) and gamma-enolase (ENO2), both involved in catalyzing the conversion of 2-phosphoglycerate to phosphoenolpyruvate, as well as phosphoglycerate kinase 1 (PGK1) regulating conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate21. The gene discussed is ENO2; the disease is hereditary leiomyomatosis and renal cell cancer.