We also observe several targets shown to confer synthetic lethality when silenced in FH mutant cell lines22 to be altered within HLRCC vs NS ULMs including succinate dehydrogenase at the protein level in HLRCC ULMs (SDHA, 0.65 logFC, adjusted p = 7.77E−05), which catalyzes the conversion of succinate to fumarate, as well as lactate dehydrogenase. The gene discussed is FH; the disease is hereditary leiomyomatosis and renal cell cancer.