Several co-quantified protein targets exhibited multiple 2SC peptides and include thioredoxin (TXN), a redox-regulated protein that mediates dithiol-disulfide exchanges and S-nitrosylation of cysteine residues in multiple target proteins and is a direct target of TXNRD1 that we quantified as elevated in HLRCC versus NS ULMs24,25. The gene discussed is TXN; the disease is hereditary leiomyomatosis and renal cell cancer.