For example, CEP72, the gene encoding a centrosomal protein associated with regulation of cell cycle, harbors an active promoter marked with H3K27ac and ATAC-Seq chromatin accessibility in normal colon tissue, and becomes transcriptionally upregulated in colon cancer with an increase in both H3K27ac and ATAC-Seq accessibility (Fig. 1e). The gene discussed is CEP72; the disease is malignant colon neoplasm.