Interestingly, nearly half (762/1,543) of upregulated PRC2+-CGI genes were also hypermethylated in other cancer types, including some known tumor suppressors, such as DKK1, NFGR, PRICKLE1. For example, DKK1 was hypermethylated in LumBRCA, PRAD and KIRC, whereas it became upregulated in BasalBRCA, LUAD/LUSC, HNSC and EAC. Here, DKK1 is linked to cancer.