HNF4A and cancer: Enhancer motifs in PRC2+-CGI genes tended to have the reported cancer-type-specific functions such as HNF4A in GI cancers (EAC, COAD, READ)45, TP63 in squamous cancers (LUSC, HNSC and a subset of BLCA)46, PAX8 in KIRC47 and UCEC48, etc. In contrast, PRC2−-CGI genes had fewer motifs overall and fewer examples corresponding to established roles in cancer.