RUNX1 and acute myeloid leukemia: We observed large differences for the APS genes CD109, CALCRL, and TMEM273. Interestingly, CD109 was previously identified as being upregulated in RUNX1-mutated AMLs44, and CALCRL has also recently been described as being over-expressed in the immature CD34+CD38− compartment of AML patient marrow45.