AKT2 and T-cell leukemia: Remarkably, using a Z score threshold > 3.5, we identified 98 selective dependency genes in CUX1−/− cells including both AKT1 and AKT2, with respective ranks at positions 24 and 96 in our screen (Z score; AKT1 = 4.81, AKT2 = 3.53), suggesting that CUX1-deficient AML cells could also be more dependent on PI3K signaling consistent with our previously reported sensitivity of CUX1-deficient T-cell leukemias to PI3K inhibition18 (Fig. 1d).