Here, we focussed on the chromosome 7q homeodomain transcription factor CUX1 (also known as CUTL1 or CDP) which is targeted by monoallelic chromosome 7 deletions [-7/del(7q)] and somatic, heterozygous, truncating mutations in diverse myeloid malignancies such as myelodysplasia (MDS) and myelodysplasia/myeloproliferative neoplasms (MDS/MPN)—both of which can progress to AML15–19. This evidence concerns the gene CUX1 and myelodysplastic syndrome.