Although samples showed genetic heterogeneity and variable colony-forming capacity, the two available -7/del(7q) AML cases displayed sensitivity to birinapant treatment, while normal karyotype and healthy-donor CD34+ samples remained largely unaffected, supporting a potential relationship between CUX1 gene dosage and sensitivity to birinapant (Fig. 8g and Supplementary Fig. 10c). Here, CUX1 is linked to acute myeloid leukemia.