To assess whether leukemias were transplantable, we injected 2 × 105 bone marrow cells from two Cux1+/−;Flt3ITD mice diagnosed with AML or Flt3ITD mice along with the same number of wild-type bone marrow support cells into irradiated recipient wild-type mice. The gene discussed is CUX1; the disease is acute myeloid leukemia.