POU2F2 directly promotes the transcription of PDPK1, and then POU2F2 interacts with AKT and activates PI3K/AKT/mTOR pathway to increase the expression of GLUT1, HK2 and PKM2, leads metabolic shift towards aerobic glycolysis and promotes GBM progression. Here, PDPK1 is linked to glioblastoma.