In consistency, as shown by immunoblot analysis of kidney homogenates and by immunohistochemistry staining, renal expression of fibrous ECM components like fibronectin or collagen I was drastically increased, with the majority being located to renal tubulointerstitium (Fig. 6E–G), indicative of progressive CKD and kidney fibrosis. The gene discussed is FN1; the disease is chronic kidney disease.