In the present paper, we demonstrated, for the first time, that1: isoform 1 of the sodium–calcium exchanger is a new target of the transcriptional factor MTF-12; the plasma membrane sodium/calcium exchanger 1 may take part in the stroke neuroprotection elicited by remote limb postconditioning; and3 MTF-1 mediates NCX1 upregulation occurring in the remote post-conditioned brain, thus taking part to stroke neuroprotection. The gene discussed is MTF1; the disease is Stroke.