MCM8 and urinary bladder carcinoma: In order to evaluate the biological implications of MCM8 in bladder cancer progression, T24 cells were transfected with RNAi targeting MCM8 (RNAi-11106, RNAi-11107, RNAi-11108), three of which successfully reduced the expression of MCM8 as evidenced by qRT-PCR analysis, especially RNAi-11108 (Fig. 1c).