Critical factors taking part in arachidonic acid metabolism regulate tumor growth and therapeutic resistance, such as Acyl-CoA synthetase 4 (ACSL4) in prostate tumor [53], hypermethylated genes in esophageal squamous cell carcinoma [54], the coding gene of epoxide hydrolase 2 (EPHX2) in prostate cancer [55], 12-lipoxygenase (12LOX) in ovarian cancer [56], etc. Thus, arachidonic acid metabolic pathway participates in the development of malignancies. The gene discussed is EPHX2; the disease is prostate cancer.