This region also regulates the degree of EGF-stimulation-dependent tyrosine phosphorylation of GAREM2.<h4>Conclusions</h4>Our results, showing that aggregation of GAREM2 in response to EGF stimulation is dependent on a glycine-rich region, suggest that GAREM2 aggregation may be involved in neurodegenerative diseases. This evidence concerns the gene GAREM2 and neurodegenerative disease.