Significantly more FOXP3-high TILs were observed in invasive pathological subtypes than in non-invasive ones.<h4>Conclusion</h4>Comparing TMEs among MPLCs revealed that non-smokers or light smokers and females were unlikely to express PD-L1 regardless of tumor site and confirmed that the EGFR mutations and co-occurring KRAS and STK11 or TP53 mutations were associated with TME. Here, EGFR is linked to neoplasm.