Although the role of blood meal in resistance to entomopathogenic fungi is unknown amongst mosquitoes, Cabral and co-workers indicated that Ae. aegypti females fed by mouse blood demonstrate higher resistance to infection by Metarhizium anisopliae than those fed with sugar, suggesting that blood components play key roles in the mosquito immune system possibly thought the rapid induction of Toll and IMD signalling pathways [81]. The gene discussed is TLR4; the disease is infection.