Of the 69 host proteins investigated in CSF samples, the levels of lipocalin-2, soluble receptor for advanced glycation end products (sRAGE), and interferon-gamma inducible protein (IP) -10 (CXCL10) were significantly higher in children who had TBM-related stroke compared to TBM without stroke, while the levels of soluble vascular cell adhesion molecule (sVCAM)-1, metalloproteinase matrix (MMP)-1, and platelet derived growth factor (PDGF)-AA were increased in children with TBM without stroke compared to TBM with stroke. The gene discussed is MMP1; the disease is Stroke.