Assessment of the abilities of the individual biomarkers to indicate stroke using ROC curve analysis showed that 23 of the 69 proteins, namely GDF-15, D-dimer, ADAMTS13, MCP-`1, IL-4, CC4b, IL-7, ferritin, IL-10, SAA, I-309, CC5a, lipocalin-2, myoglobin, CC2, IL-13, RANTES, IL-1β, GDNF, serum amyloid P, MIP-1α, CC3, and PDGF-AB/BB indicated stroke in children with TBM with AUC ≥0.70 (S3 Table). The gene discussed is GDNF; the disease is stroke disorder.