In addition, we observed trends (0.05<p-value≤0.09) in increased levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), D-dimer and Brain-derived neurotrophic factor (BDNF), and lower levels of ferritin and apolipoprotein CIII were observed in children who had TBM-related stroke compared to TBM without stroke. The gene discussed is BDNF; the disease is Stroke.