The most accurate serum protein biosignature by GDA comprised IL-1β, IL-4 and alpha-1-Antitrypsin (A1AT), and indicated stroke amongst children with TBM with an AUC of 1.00 (95% CI, 1.00–1.00), associated to sensitivity of 100.0% (95% CI, 80.7%-100.0%) (14/14) and specificity of 88.9% (95% CI, 51.8%-99.7%) (8/9). Here, IL1B is linked to stroke disorder.