AKT1 and melanoma: Furthermore, with respect to inactivity of sporozoites it is interesting to mention that Prominin-1/CD133, one of the two human orthologs of the Prominin gene (PF3D7_0104100), is known as a marker for dormant stem cells, e.g. in melanoma [80] or in Neural cells [81], and has been shown to activate the PI3K/AKT pathway [82].