Supplementary Figure 5 demonstrates several representative Kaplan–Meier maps; four methylation sites in BDNF, two methylation sites in PIK3R1, and one methylation site in TSC2, ZNF746, and EOMES could be used to group the patients with HCC in high- and low-risk groups with significant differences in OS (Supplementary Figure 5). The methylation statistics of BDNF and PIK3R1 were significantly correlated with the OS of patients with HCC (Figure 7A, 7D). This was also confirmed by the methylation information from MEX.PRESS website (Figure 7G, 7H). This evidence concerns the gene PIK3R1 and hepatocellular carcinoma.