In a recent pan-cancer analysis of oncogenic pathways, WNT signaling was shown to be altered in around two-thirds of IDH-mutant, 1p/19q-codeleted low-grade gliomas, i.e. ODs according to the WHO classification of 2016 [37], in that they exhibited inactivation of the TCF7 gene [53]. Here, TCF7 is linked to central nervous system cancer.