HEK293T A817V knock-in cells exhibited higher nuclear levels of active β-catenin compared to WT/WT cells (Fig. 3l,m), and treatment with the MNK1 inhibitor CGP 57380 downregulated β-catenin levels in the nucleus of nasopharyngeal carcinoma cell lines [62]. The gene discussed is MKNK1; the disease is nasopharyngeal carcinoma.