Genes found as targets of the most frequently expressed miRNAs in glaucoma were associated with the cardiovascular system development, response to hypoxia, apoptosis, cytoplasm compartment, enzymatic activity, cancer, FoxO, PI3K-AKT and HIF-1 signalling pathways, viral infections, blood coagulation cascade, and regulation of inflammation. This evidence concerns the gene AKT1 and viral infectious disease.