CDH1 and cancer: In the context of cancer, cells with punctate E-CADHERIN localization represent an intermediate epithelial-mesenchymal state (Sha et al., 2019; Yang et al., 2020), characterized by an increased propensity for collective invasion and metastasis (Aiello et al., 2018; Ayollo et al., 2009; Gloushankova et al., 2017; Jolly et al., 2015; Kovac et al., 2018; Saitoh, 2018).