In cancer, a cytoskeleton-mediated switch from linear to punctate E-CADHERIN results in weaker cell-cell adhesion and loss of epithelial integrity (Aiello et al., 2018; Ayollo et al., 2009; Gloushankova et al., 2017; Jolly et al., 2015; Kovac et al., 2018; Saitoh, 2018). Here, CDH1 is linked to cancer.