RREB1 and cancer: Moreover, mutation or altered expression of Rreb1 has been linked to leukemia (Yao et al., 2019), melanoma (Ferrara and De Vanna, 2016), thyroid (Thiagalingam et al., 1996), and prostate (Mukhopadhyay et al., 2007) cancers, as well as pancreatic and colorectal cancer metastasis (Cancer Genome Atlas Research Network.