Four Bonferroni significant DMR were identified in islands, which were located near the following genes: LTB, a cytokine shown to stimulate osteoclast activity; SKIV2L, with an RNA helicase activity, thought to be involved in blocking translation of viral mRNA and has been implicated in regulating host responses to viral infections (Eckard et al., 2014); EBF3, which is involved in bone development and B cell differentiation (Seike et al., 2018); and CCND1, a Wnt target that was reported to be upregulated in response to mechanical loading of bone (Holguin et al., 2016). The gene discussed is CCND1; the disease is viral infectious disease.