TRPV1 and inflammatory bowel disease: After the acute phase of infection or inflammation, the immune system releases soluble factors, such as resolvins and neuroprotectins, that indirectly desensitize nociceptive sensory neurons and reduce pain.130,131 In chronic conditions such as IBD, patients have increased expression of TRPV1 nociceptors alongside increased abdominal pain.132–134 However, the role of nociceptors in IBD is still unknown.