This result is consistent with recent reports of a reduction in ACE2 and TMPRSS2 expression in patients with chronic rhinosinusitis with nasal polyps, compared to controls.18 In another report, ACE2 expression was reduced in the nasal and airway epithelial cells in patients with type 2 asthma and allergic rhinitis.19 The latter report speculated that the lower ACE2 expression in eosinophilic and allergic airway inflammation conditions indicated a potential regulatory effect. This evidence concerns the gene ACE2 and chronic rhinosinusitis.