Recently, it was reported that in heavily pre-treated patients (refractory to chemotherapy, anti-VEGF, and anti-EGFR therapy [for tumours with wild-type RAS]) biweekly administration of FTD/TPI with bevacizumab showed promising anti-tumour activity with acceptable toxicity and dramatically decreased CIN compared with the standard combination treatment schedule [20]. This evidence concerns the gene EGFR and neoplasm.