The proliferate rate of PCNA in CPDP NPs + LIFU group was only 20.50%, which was fourfold lower than control group, threefold lower than LIFU and CPDP NPs only group and twofold lower than PDP + LIFU group, respectively, demonstrating a significant anti-tumor proliferation rate (Fig. 8e). This evidence concerns the gene PCNA and neoplasm.