AGER and cancer: While on the other hand, the treatment group of the cancer tissue with PFT-HSA-TFT-Cy7 and PFT-Hcy-HSA-Cy7 shows a significant decrease in the level of RAGE mRNA, with an average decrease in fold change as 2.0-fold and 1.91-fold at 1 μM and 2.5-fold and 1.6-fold at 3 μM concentration of nanoassemblies (Figure 6(a)).