Li et al. reported that the expression level of NRF2 and its target genes heme oxygenase 1 (HO-1) and NAD(P)H quinone dehydrogenase 1 (NQO1) increased significantly in the heart of obese T2DM mice, but they decreased in the hearts of non-obese T2DM mice (15). This evidence concerns the gene NFE2L2 and type 2 diabetes mellitus.