These findings are in agreement with previous findings showing that D-tagatose, as a carbohydrate source, did not promote obesity and hyperglycemia and these effects were associated with lower risk of hypercholesterolemia and atherosclerosis, in comparison to sucrose, when tested in low-density lipoprotein receptor deficient (LDLr–/–) mice (Police et al., 2009). Here, VLDLR is linked to familial hypercholesterolemia.