A study in rats has recently demonstrated that sugar-induced obesity may significantly contribute to increased propensity of the heart to malignant arrhythmias by interfering with expression and activity of myocardial electrical coupling protein, connexin-43, and protein kinase C signaling cascade (Egan Benova et al., 2019). This evidence concerns the gene GJA1 and obesity due to melanocortin 4 receptor deficiency.