The significant difference in expression levels of hydroxyproline, whose measurements accurately reflect the amount of collagen in the tissue, and GDF8, a reliable marker of clinical severity after acute myocardial infarction (Meloux et al., 2019), which were both maximally upregulated in the I/R heart of fructose-fed rats and only slightly overexpressed in the presence of D-tagatose, is a further evidence of the limited toxic impact of D-tagatose diet on cardiac damage after I/R when compared to a fructose rich diet. This evidence concerns the gene MSTN and acute myocardial infarction.