Meanwhile, AKR1C1 (HR: 1.372, 95% CI: 1.006–1.872, p = 0.046), HMGCR (HR: 2.666, 95% CI: 1.350–5.262, p = 0.005), TFRC (HR: 2.662, 95% CI: 1.337–5.299, p = 0.005), SQLE (HR: 2.432, 95% CI: 1.224–4.833, p = 0.011) and PGD (HR: 3.131, 95% CI: 1.484–6.609, p = 0.003) were risk factors for thyroid cancer prognosis (Figure 1G). The gene discussed is AKR1C1; the disease is thyroid cancer.