Also, transcription regulators (e.g., nuclear factor-kappa B, mitogen-activated protein kinases, and phosphoinositide-3 kinase/protein kinase-B) are found in thyroid cancer, and these promote the proliferation of oncogenes in the TME, which is in turn related to the thyroid cancer subtype (Ferrari et al., 2020). This evidence concerns the gene WNK2 and thyroid cancer.