IL15 and neoplasm: This prior lymphoconditioning provides advantages for the performance of adoptive cell therapies since it eliminates regulatory T cells and other cells that suppress the immune response in the tumor and increases the levels of IL-7 and IL-15 available for the transferred cells, recreating homeostatic conditions (Gattinoni et al., 2006; Restifo et al., 2012; Hinrichs and Rosenberg, 2014).