Elevated levels of IL-6 and IL-8 are associated with paracrine secretion in the SASP phenotype, and vitamin D3 has been proven to exert anti-inflammatory effects in prostate cancer through the inhibition of IL-6, IL-8, and TNF-α (Giangreco et al., 2015). The gene discussed is CXCL8; the disease is prostate carcinoma.