Nevertheless, taking advantage of the power of genome-level approach, Dand5 KO cells revealed significant changes in genes related to ECM-receptor interaction, dilated cardiomyopathy, hypertrophic cardiomyopathy, adrenergic signaling in cardiomyocytes, cardiac muscle contraction, calcium signaling, cell adhesion molecules, tight junctions, among other biological processes. Here, DAND5 is linked to dilated cardiomyopathy.