Nevertheless, taking advantage of the power of genome-level approach, Dand5 KO cells revealed significant changes in genes related to ECM-receptor interaction, dilated cardiomyopathy, hypertrophic cardiomyopathy, adrenergic signaling in cardiomyocytes, cardiac muscle contraction, calcium signaling, cell adhesion molecules, tight junctions, among other biological processes. The gene discussed is DAND5; the disease is hypertrophic cardiomyopathy.