AKT1 and hypertrophic cardiomyopathy: Then, a KEGG pathway enrichment analysis of the differentially expressed genes was carried out and suggested that upregulated differentially expressed genes were involved in pathways such as dilated cardiomyopathy, hypertrophic cardiomyopathy, PI3K-Akt signaling pathway, cardiac muscle contraction or calcium signaling pathway (Figure 5D).