This evidence suggests that TRPM8 might converge to a common HGF/SF and cMET, known to play a role in malignancy of solid tumors including glioma (Laterra et al., 1997; Birchmeier et al., 2003; Wondergem et al., 2008), signaling pathway leading to migration/invasion. Here, TRPM8 is linked to glioma.