TRPC1 and central nervous system cancer: Interestingly, all the TRPC1 effects on glioma cell behavior strictly resulted from lipid regulation, e.g., in some cases the channel activity is directly affected by lipids [phosphatidylinositol-(4,5)-bisphosphate PIP2, phosphoinositides, diacylglycerol, cholesterol, etc.] localized on the plasma membrane, in other cases, it can be by signaling pathways which lead to the production of specific lipids such as sphingolipids.