TRPV2 and glioblastoma: In this context, recent developments on the role of the so-called “pore turret,” i.e., the region of the extracellular ring that connects the S5 helix to the pore helix, in controlling the upper gate of some TRP channels including TRPV2 (Dosey et al., 2019) have provided new insights into the role of TRPV2 as a drug target to reduce GBM chemoresistance.