Similar findings were also observed in hepatocellular carcinoma in which TRPV2 activation by CBD or 2-APB (Aminoethoxydiphenyl borate) was found to improve DOXO permeation into tumor cells, thus corroborating an intriguing role of TRPV2 in increasing tumor cell sensitivity to chemotherapy drugs (Neumann-Raizel et al., 2019). The gene discussed is TRPV2; the disease is hepatocellular carcinoma.