More specifically, it has been demonstrated that under hypoxia, which is one of the main characteristics of GBM aggressiveness, invasion and resistance to treatment (Flynn et al., 2008), Notch1 activation consequently led to TRPC6 upregulation in primary GBM samples and cell lines (Chigurupati et al., 2010). The gene discussed is TRPC6; the disease is glioblastoma.