TRPC6 and neoplasm: Mechanistically, TRPC6 effects on cell proliferation, tumor growth and angiogenesis seemed to be directly mediated by the Ca2+-induced activation of the calcineurin-NFAT pathway (Chigurupati et al., 2010), whereas TRPC6 effects on cell migration might rather involve Rho activation and subsequent actin cytoskeleton rearrangements (Singh et al., 2007).