Specifically, by using the natural red fluorescent DOXO, it has been demonstrated that TRPV2 overexpression in MZC glioma cells markedly increased DOXO uptake in a Ca2+-dependent manner, since Ca2+ chelation by EGTA completely inhibited the CBD-induced TRPV2-mediated increase of DOXO-positive cells (Nabissi et al., 2013). This evidence concerns the gene TRPV2 and central nervous system cancer.