TRPM8 and glioblastoma: It has been shown that TRPM8 activation by icilin leads to a significant increase in the migration speed and chemotaxis of GBM cells and, consistently, TRPM8 downregulation by RNA interference as well as TRPM8 inhibition by the specific channel blocker BCTC [N-(4-tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tet rahydropyrazine-1(2H)-carbox-amide] reduces cell migration rate and decreases transfilter chemotaxis (Klumpp et al., 2017).