Such observation was linked to the up-regulation of the transcriptional activator of the TRPML-2 gene Paired box 5 (PAX5) (Valadez and Cuajungco, 2015) found in human astrocytoma and correlated with malignancy and pathological grade of glioma (Stuart et al., 1995). This evidence concerns the gene PAX5 and central nervous system cancer.