A recent study by Zeng et al. (2019) have suggested an involvement of the mitogen-activated protein kinase (MAPK) signaling pathway in TRPM8-mediated effects on cell proliferation and apoptosis, since the expression of the channel was associated with the expression levels of important regulators of these pathways, including extracellular signal-regulated kinase (ERK), cyclin D1 and the apoptosis-related protein Bcl-2 in human glioma cells. The gene discussed is TRPM8; the disease is central nervous system cancer.