TRPC1 and central nervous system cancer: Moreover, the disruption of lipid rafts by depletion of cholesterol not only affected chemotaxis but also impaired TRPC currents in whole-cell recordings and decreased store-operated Ca2+ entry (SOCE), confirming a direct interplay between lipid rafts and TRPC1 channels and localized Ca2+ rise in regulating the chemotactic movement of glioma cells (Bomben et al., 2011).