The important role of TRPC1 in glioma cell division has been also confirmed in vivo through a shRNA knockdown approach on a flank GBM cell tumor model: TRPC1 downregulation led to a significant decrease in tumor size, most likely impairing calcium signaling during cytokinesis (late M-phase) (Bomben and Sontheimer, 2010). Here, TRPC1 is linked to central nervous system cancer.