TRPC6 and central nervous system cancer: For instance, mRNA encoding TRPC1, TRPC6, TRPM7, TRPM8, TRPV4, and TRPML2 appeared up-regulated in GBM tumor specimens in comparison with normal tissues and their expression was found to increase with glioma tumor grade with the highest mRNA level found in GBM patient samples (Ding et al., 2010; Alptekin et al., 2015).