In particular, it has been shown that TRPC1 is essential for chemotactic migration in human malignant gliomas in response to chemoattractant growth factors like epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) which affect TRPC1 activity through different signaling pathways (Bomben et al., 2011; Lepannetier et al., 2016). The gene discussed is EGF; the disease is malignant glioma.