But in A172 human GBM cells the transfection with TRPM2 channels increased cell death induced by H2O2 in a Ca2+-dependent manner (Ishii et al., 2007) and in human GBM (DBTRG) cells, TRPM2 activation led to an increase in oxidative stress and intracellular Ca2+ concentration, thus promoting GBM cell death through apoptosis (Ertilav et al., 2019). Here, TRPM2 is linked to glioblastoma.