The anti-tumorigenic functional role of TRPV1 in gliomas, suggested by its marked downregulation or loss in patients with the shortest overall survival, has been investigated and several findings highlighted a role of TRPV1 in the induction of apoptotic cell death signaling in gliomas (Amantini et al., 2007; Stock et al., 2012). The gene discussed is TRPV1; the disease is glioma.