In agreement, ionizing radiation, known to induce the migration through a Ca2+-mediated activation of BK channels (Steinle et al., 2011; Edalat et al., 2016), has been shown to activate and upregulate TRPM8-mediated Ca2+ influx in glioma cells (Klumpp et al., 2017), thus confirming a direct and reciprocal interplay between these two channel families in the control of GBM migration. The gene discussed is TRPM8; the disease is glioma.