TRPM8 was found to affect the rate of GBM cell migration by mediating a significant increase in intracellular Ca2+ concentration upon stimulation with specific agonists such as menthol and icilin (Wondergem et al., 2008; Wondergem and Bartley, 2009; Klumpp et al., 2017). Here, TRPM8 is linked to glioblastoma.