However, TRPML1 expression at mRNA and protein levels displayed variability within patient samples and its subcellular localization may also be distinct since TRPML1 is mainly expressed in the late endosome/lysosome of normal cells while found in endolysosomes and as dot spots in the nuclear cell compartment in glioma cells (Morelli et al., 2019). Here, MCOLN1 is linked to central nervous system cancer.