More specifically, TRPM7 expression can be associated with a decreased production of miR-28-5p, a tumor suppressor inhibiting the expression of oncogenic signaling pathways involving protein-kinase B (AKT) (Xiao et al., 2018), ERK (Liu et al., 2016), and IGF-1 (Shi and Teng, 2015). The gene discussed is AKT1; the disease is neoplasm.