However, these results have to be taken with caution in a future context of drug therapy, since TRPM8 was shown to have an anti-migratory activity in other cancers including prostate cancer and may play a role in the tumoral and tumor-derived endothelial cells (Gkika et al., 2010, 2015; Genova et al., 2017; Grolez et al., 2019b). This evidence concerns the gene TRPM8 and neoplasm.