Such observation was linked to the up-regulation of the transcriptional activator of the TRPML-2 gene Paired box 5 (PAX5) (Valadez and Cuajungco, 2015) found in human astrocytoma and correlated with malignancy and pathological grade of glioma (Stuart et al., 1995). The gene discussed is MCOLN2; the disease is glioma.