Similarly, the involvement of NLRP3 inflammasome can also be observed in various CNS diseases such as infection, ischemia, and degeneration (Marim et al., 2017; Heneka et al., 2018; Katuri et al., 2019; Xue et al., 2019; Cui et al., 2020; Ji et al., 2020; Ma et al., 2020; Zeng et al., 2020). The gene discussed is NLRP3; the disease is infection.