For instance, understanding the role of CCDC80 in repressing EMT markers and consequently pancreatic cancer cell invasion and migration indicates the value of vactosertib-nal-IRI/5-FU/LV combination, which demonstrates a higher variance in activating CCDC80 and further repressing EMT markers than the monotherapy with vactosertib. The gene discussed is CCDC80; the disease is pancreatic neoplasm.