For instance, due to its strong effects on phenotypic plasticity and colonization capacity of pancreatic tumor cells, EMT-TF Zeb1 drives pancreatic tumour progression to late-stage metastasis, in contrast to no effects found for the EMT-TFs Twist and Snail on pancreatic cancer cell metastasis (12). The gene discussed is TWIST1; the disease is pancreatic neoplasm.