NFKB1 and inflammatory bowel disease: In antigen-presenting cell (APC) mutant mice model which are predisposed to intestinal cancer formation, the enterotoxigenic B. fragilis (ETBF), one of the two subtype of B. fragilis, can induce colitis and inflammatory bowel disease (IBD) through the pathway of β-catenin/Wnt/NF-κB signaling, and further lead to the oncogenesis of CRC (15).