RHOA and angioimmunoblastic T-cell lymphoma: Of note, G17V RhoA mutant acquires the ability to significantly increase and to enhance the Inducible T Cell Costimulator (ICOS) signaling leading to the differentiation of CD4+ T cells towards the follicular helper T lineage (45, 46), suggesting that G17 RhoA profoundly modifies the transcription program of these neoplastic cells leading to the establishment of the follicular helper T, unique features of AITL.