AKR1C1 and non-small cell lung carcinoma: Mechanistically, depletion of YTHDF1 can inhibit the translational efficiency of m6A-modified Keap1 mRNA in an oxidative stress state induced by DDP, and activated the antioxidant ROS clearance system (Nrf2-AKR1C1) in turn, leading to DDP resistance and a worse clinical outcome for NSCLC patients (62).