PLCG1 and neoplasm: To further investigate whether ACAD8-T105I, BCAR1-G23V and PLCG1-M425L peptides can serve as potent vaccines against tumor growth in vivo, HLA-A2.1/Kb transgenic mouse-derived NRTs were adoptively transferred into H522/Kb-minigene human lung cancer-bearing C57BL/6 nude mice.