Furthermore, we discover epithelial-mesenchymal transition signaling (49), TNFαsignaling via NF-κB (50), IL-2/STAT5 signaling (36), interferonγ response signaling and some other pathways are activated in high risk group, most of which trigger tumor cells malignant progression, immune evasion, metastasis and poor prognosis. The gene discussed is IL2; the disease is neoplasm.